Nikisha Fogo was born in Stockholm, Sweden and is of Swedish and Jamaican descent. Her parents owned the first hip-hop dance school in Sweden, and she dabbled in different dance styles such as hip-hop, jazz, and tap. At age 10, Fogo entered the Royal Swedish Ballet School. The following year, she auditioned for Talang 2007.
In 2011, shortly after she turned 16, Fogo competed at the Prix de Lausanne; where she was offered several scholarships to leading European dance companies and was invited by Gailene Stock, the director of The Royal Ballet School in London, to train in London. Fogo attended the school's second and third years of the Upper School, with a scholarship provided by the Anglo-Swedish Society. She graduated in 2013.
Fogo joined the Vienna State Ballet in 2013. She was promoted to demi-soloist in 2015 and soloist the following year. As a soloist, she danced the principal role in Theme and Variations. In 2018, she was chosen to dance the title role in artistic director Manuel Legris's reconstruction of Sylvia, which was also Fogo's first full-length principal role. After the performance, Legris promoted Fogo to the rank of the first soloist, the highest rank of the company. She went on to dance principal roles in other productions.
In 2020, Fogo was appointed as a principal dancer to the San Francisco Ballet, after she had auditioned for the company was touring in London. Helgi Tomasson, the artistic director of the company, said Fogo "has everything I look for in a principal dancer—strong and versatile technique to excel in the classical and contemporary repertoire, beautiful musicality and a profound desire to dance".
Fogo was originally scheduled to relocate to the U.S. in July but had to delay due to the COVID-19 pandemic. During this time, she danced The Swan in Misty Copeland's fundraiser, Swans for Relief, a response to the pandemic's impact on the dance community, with funds going to participating dancers' companies and other related relief funds. She made her San Francisco Ballet debut at their virtual gala in January 2021 with Julian Mackay and danced the White Swan Pas de Deux from Swan Lake and the Don Quixote Pas de Deux.